NHL Standard
| Scoring | Goals | Assists | Shots | Ice Time | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Season | Age | Tm | Lg | GP | G | A | PTS | +/- | PIM | EV | PP | SH | GW | EV | PP | SH | S | S% | TSA | TOI | ATOI | FOW | FOL | FO% | BLK | HIT | TK | GV | Awards |
| 2007-08 | 19 | NYI | NHL | 9 | 2 | 3 | 5 | 3 | 2 | 1 | 1 | 0 | 1 | 2 | 0 | 1 | 15 | 13.3 | 27 | 148 | 16:28 | 0 | 0 | 3 | 5 | 4 | 1 | ||
| 2008-09 | 20 | NYI | NHL | 65 | 18 | 21 | 39 | -6 | 36 | 9 | 9 | 0 | 3 | 16 | 4 | 1 | 165 | 10.9 | 314 | 1171 | 18:01 | 5 | 10 | 33.3 | 30 | 64 | 76 | 30 | Calder-14 |
| 2009-10 | 21 | NYI | NHL | 80 | 19 | 33 | 52 | -22 | 34 | 15 | 4 | 0 | 4 | 14 | 18 | 1 | 249 | 7.6 | 460 | 1643 | 20:32 | 33 | 36 | 47.8 | 44 | 62 | 78 | 65 | |
| 2010-11 | 22 | NYI | NHL | 38 | 5 | 15 | 20 | 3 | 40 | 5 | 0 | 0 | 2 | 10 | 5 | 0 | 72 | 6.9 | 163 | 630 | 16:35 | 36 | 51 | 41.4 | 16 | 31 | 26 | 22 | |
| 2011-12 | 23 | NYI | NHL | 79 | 24 | 21 | 45 | -15 | 46 | 21 | 3 | 0 | 2 | 18 | 3 | 0 | 152 | 15.8 | 279 | 1348 | 17:04 | 68 | 74 | 47.9 | 33 | 51 | 62 | 30 | |
| 2012-13 | 24 | NYI | NHL | 48 | 4 | 20 | 24 | -2 | 38 | 4 | 0 | 0 | 0 | 17 | 3 | 0 | 101 | 4.0 | 175 | 814 | 16:57 | 104 | 82 | 55.9 | 21 | 48 | 35 | 35 | |
| 2013-14 | 25 | NYI | NHL | 71 | 27 | 42 | 69 | -9 | 51 | 22 | 5 | 0 | 4 | 32 | 10 | 0 | 195 | 13.8 | 381 | 1451 | 20:26 | 97 | 107 | 47.5 | 35 | 43 | 44 | 39 | AS-11 |
| 2014-15 | 26 | NYI | NHL | 60 | 18 | 33 | 51 | -8 | 12 | 12 | 6 | 0 | 2 | 21 | 12 | 0 | 195 | 9.2 | 349 | 1173 | 19:33 | 80 | 81 | 49.7 | 23 | 53 | 30 | 45 | Byng-48 |
| 2015-16 | 27 | NYI | NHL | 79 | 22 | 42 | 64 | -4 | 51 | 15 | 7 | 0 | 4 | 26 | 16 | 0 | 202 | 10.9 | 376 | 1438 | 18:12 | 23 | 40 | 36.5 | 39 | 90 | 42 | 54 | |
| 2016-17 | 28 | BUF | NHL | 65 | 19 | 26 | 45 | -7 | 24 | 12 | 7 | 0 | 2 | 10 | 16 | 0 | 156 | 12.2 | 284 | 1233 | 18:58 | 54 | 45 | 54.5 | 25 | 53 | 26 | 36 | |
| 2017-18 | 29 | BUF | NHL | 76 | 15 | 29 | 44 | -34 | 40 | 9 | 6 | 0 | 2 | 14 | 15 | 0 | 161 | 9.3 | 279 | 1294 | 17:02 | 23 | 27 | 46.0 | 34 | 70 | 24 | 28 | |
| 2018-19 | 30 | BUF | NHL | 78 | 14 | 15 | 29 | -9 | 41 | 7 | 7 | 0 | 2 | 11 | 4 | 0 | 147 | 9.5 | 232 | 1075 | 13:47 | 63 | 71 | 47.0 | 27 | 87 | 17 | 27 | |
| 2019-20 | 31 | BUF | NHL | 52 | 9 | 10 | 19 | -3 | 28 | 8 | 1 | 0 | 2 | 10 | 0 | 0 | 82 | 11.0 | 133 | 668 | 12:51 | 38 | 33 | 53.5 | 15 | 55 | 15 | 13 | |
| 9 yrs | NYI | NHL | 529 | 139 | 230 | 369 | -60 | 310 | 104 | 35 | 0 | 22 | 156 | 71 | 3 | 1346 | 10.3 | 2524 | 9817 | 18:33 | 446 | 481 | 48.1 | 244 | 447 | 397 | 321 | ||
| 4 yrs | BUF | NHL | 271 | 57 | 80 | 137 | -53 | 133 | 36 | 21 | 0 | 8 | 45 | 35 | 0 | 546 | 10.4 | 928 | 4270 | 15:45 | 178 | 176 | 50.3 | 101 | 265 | 82 | 104 | ||
| Career | 13 yrs | NHL | 800 | 196 | 310 | 506 | -113 | 443 | 140 | 56 | 0 | 30 | 201 | 106 | 3 | 1892 | 10.4 | 3452 | 14087 | 17:37 | 624 | 657 | 48.7 | 345 | 712 | 479 | 425 | ||
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